Bioorganic Chemistry: Models and Applications
Thompson and Erik C.
Proctor Academy Main Street. Conference Description.
Highlights in Bioorganic Chemistry: Methods and Applications
The Bioorganic Chemistry Gordon Research Conference GRC , established in , brings together interdisciplinary scientists pursuing challenges at the interface of chemistry and biology. Attendees from industry, academia and other research institutions convene annually to discuss the latest molecular approaches and tools to understand, probe and modulate biological complexity. The edition will broadly focus on the structure-function relationships in biomolecular recognition with an emphasis on the role of weak forces and dynamics, with specific sessions on biopharmaceuticals, conformational disorder in recognition, and translation of chemical biology approaches to new drugs and materials.
Conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. A number of poster presenters will be invited to present short talks.
As this meeting usually oversubscribes, submission of applications in early is strongly encouraged. Related Meeting.
Conference Program. Sunday pm - pm Arrival and Check-in. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Jeanne Magram Northern Biologics, Canada.
Stacie S. Andy Crew Arvinas, Inc. Hiroaki Suga University of Tokyo, Japan. New cytotoxic tricycloalternarenes from fungus Alternaria brassicicola November Immunomodulatory activities of zinc II phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagents November Design and synthesis of novel pyridazinoquinazoline derivatives as potent VEGFR-2 inhibitors: In vitro and in vivo study November Promising antibacterial agents against multidrug resistant Staphylococcus aureus November Chemical constituents from Alismatis Rhizoma and their anti-inflammatory activities in vitro and in vivo November Design and evaluation of non-carboxylate 5-arylidenethioxoimidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B November First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents November Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease November Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors November Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitors November Tyrosinase inhibitory effects of Vinca major and its secondary metabolites: Enzyme kinetics and in silico inhibition model of the metabolites validated by pharmacophore modelling November Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents November Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N- 4-methylpyridinyl thiophenecarboxamide analogs November Xanthones from the stems of Cudrania tricuspidata and their inhibitory effects on pancreatic lipase and fat accumulation November Novel 3,4-dihydrooxoquinazoline-based acetohydrazides: Design, synthesis and evaluation of antitumor cytotoxicity and caspase activation activity November Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity November The application of safe for humans and the environment Polyversum antifungal agent containing living cells of Pythium oligandrum for biotransformation of prochiral ketones November Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials November Physapubescin I from husk tomato suppresses SW cancer cell growth by targeting kidney-type glutaminase November Coumarin tethered cyclic imides as efficacious glucose uptake agents and investigation of hit candidate to probe its binding mechanism with human serum albumin November Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis November Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs November New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity November Novel N-benzylpyridinium moiety linked to arylisoxazole derivatives as selective butyrylcholinesterase inhibitors: Synthesis, biological evaluation, and docking study November Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins November Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3 4H -yl furancarboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies November Bioorganic Chemistry.
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